GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6083856 | chr20:25407585 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 6.98 | 9.75E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083856 | chr20:25407585 | FAM182A | chr20:26035250-26067552:+ | 0.19 | 3.43 | 0.000647 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083856 | chr20:25407585 | FAM182B | chr20:25744102-25848786:- | -0.24 | -5.02 | 7.29E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083856 | chr20:25407585 | NINL | chr20:25433338-25566153:- | 0.37 | 7.53 | 2.6E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083862 | chr20:25411086 | ENTPD6 | chr20:25176339-25207360:+ | 0.33 | 7.5 | 3.23E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083862 | chr20:25411086 | FAM182A | chr20:26035250-26067552:+ | 0.19 | 3.55 | 0.000427 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083862 | chr20:25411086 | FAM182B | chr20:25744102-25848786:- | -0.25 | -5.11 | 4.56E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083862 | chr20:25411086 | NINL | chr20:25433338-25566153:- | 0.36 | 7.41 | 5.88E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083862 | chr20:25411086 | PYGB | chr20:25228706-25278647:+ | 0.15 | 3.83 | 0.000145 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs9309473 | 1 | rs60844734 | chr2:73623205 | ALMS1P | chr2:73872046-73912692:+ | 0.71 | 11.16 | 7.15E-26 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs60844734 | chr2:73623205 | NAT8 | chr2:73867850-73869537:- | 0.39 | 6.13 | 1.89E-9 | Metabolite levels |
| THCA | cis | rs16958440 | 1 | rs60854219 | chr18:44646664 | HDHD2 | chr18:44633782-44676871:- | 0.26 | 4.98 | 8.99E-7 | Sitting height ratio |
| THCA | cis | rs16958440 | 1 | rs60854219 | chr18:44646664 | PIAS2 | chr18:44392061-44500123:- | -0.15 | -3.37 | 0.000804 | Sitting height ratio |
| THCA | cis | rs867186 | 1 | rs60866116 | chr20:33726150 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.39 | 0.000753 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs60866116 | chr20:33726150 | PROCR | chr20:33758727-33765164:+ | -0.29 | -4.75 | 2.72E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |